tmRNA – a novel high-copy-number RNA diagnostic target – its application forStaphylococcus aureusdetection using real-time NASBA

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The limited angular resolution of γ–ray telescopes prevents the straight identification of the majority of the sources detected so far. This is particularly true for the low latitude, probably galactic ones, only 10 % of which has been identified. Most of the counterparts are Isolated Neutron Stars, both radio–loud and radio–quiet, characterised by an extremely high value of fX /fopt. The best ...

“Not not bad” is not “bad”: A distributional account of negation

With the increasing empirical success of distributional models of compositional semantics, it is timely to consider the types of textual logic that such models are capable of capturing. In this paper, we address shortcomings in the ability of current models to capture logical operations such as negation. As a solution we propose a tripartite formulation for a continuous vector space representat...

Integrated microfluidic tmRNA purification and real-time NASBA device for molecular diagnostics.

We demonstrate the first integrated microfluidic tmRNA purification and nucleic acid sequence-based amplification (NASBA) device incorporating real-time detection. The real-time amplification and detection step produces pathogen-specific response in < 3 min from the chip-purified RNA from 100 lysed bacteria. On-chip RNA purification uses a new silica bead immobilization method. On-chip amplific...